Article
Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.
Obesity (Silver Spring, Md.) - 1 Jan 2013
Traurig Michael T, Orczewska Julieanna I, Ortiz Daniel J, Bian Li, Marinelarena Alejandra M, Kobes Sayuko, Malhotra Alka, Hanson Robert L, Mason Clint C, Knowler William C, Bogardus Clifton, Baier Leslie J
Abstract excerpt
OBJECTIVE: A genome-wide association study (GWAS) was recently completed in 1120 Pima Indians to identify loci that influence BMI. Among the top 100 signals were three variants that mapped within the lysophosphatidylglycerol acyltransferase 1 (LPGAT1) gene. LPGAT1 belongs to a large family of acyltransferases, which are involved in a variety of biological processes including pathways that regulate energy...
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