Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.

Human genetics - 1 Nov 2014

Muller Yunhua L, Thearle Marie S, Piaggi Paolo, Hanson Robert L, Hoffman Duncan, Gene Brittany, Mahkee Darin, Huang Ke, Kobes Sayuko, Votruba Susanne, Knowler William C, Bogardus Clifton, Baier Leslie J

Abstract excerpt

Six rare functional coding mutations were previously identified in melanocortin 4 receptor (MC4R) in 6,760 American Indians. Individuals heterozygous for one of these mutations become obese while young. We now investigate whether common non-coding variation near MC4R also contributes to obesity. Fifty-six tag single-nucleotide polymorphisms (SNPs) were genotyped in 3,229 full-heritage Pima Indians, and nine of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arizona
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Indians, North American

Share to Longitudinal Studies

Share to Obesity

Share to Receptor, Melanocortin, Type 4

Source

Open in PubMed Open full text

Identifiers

PMID: 25103139
DOI: 10.1007/s00439-014-1477-6
PMCID: PMC4185108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.PMID 25103139Read ↗

Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population.Semantic proximity Read ↗

Association of MC4R (rs17782313) gene polymorphism with obesity measures in Western India.Semantic proximity Read ↗

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.Semantic proximity Read ↗

Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.Semantic proximity Read ↗

Common variants near MC4R are associated with fat mass, weight and risk of obesity.Semantic proximity Read ↗

Clinical and Functional Characterization of Melanocortin 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset obesity.Semantic proximity Read ↗

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians.Semantic proximity Read ↗

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.Semantic proximity Read ↗

Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth.Semantic proximity Read ↗

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.Semantic proximity Read ↗

The genetic epidemiology of melanocortin 4 receptor variants.Semantic proximity Read ↗

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.