Article
Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.
Annals of human genetics - 1 Sept 2018
Hsueh Wen-Chi, Bennett Peter H, Esparza-Romero Julian, Urquidez-Romero Rene, Valencia Mauro E, Ravussin Eric, Williams Robert C, Knowler William C, Baier Leslie J, Schulz Leslie O, Hanson Robert L
Abstract excerpt
Prevalence of diabetes and obesity in Mexican Pima Indians is low, while prevalence in US Pima Indians is high. Although lifestyle likely accounts for much of the difference, the role of genetic factors is not well explored. To examine this, we genotyped 359 single nucleotide polymorphisms, including established type 2 diabetes and obesity variants from genome-wide association studies (GWAS) and 96 random...
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