Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.

Mechanisms of ageing and development - 1 Apr 2009

Hinkal George W, Gatza Catherine E, Parikh Neha, Donehower Lawrence A

Abstract excerpt

The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mouse accelerated aging model that exhibits increased p53 activity, the p53(+/m) mouse. Aged tissues of p53(+/m) mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Mice, Transgenic

Share to Models, Animal

Share to Stress, Physiological

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 19396980
DOI: 10.1016/j.mad.2009.01.001
PMCID: PMC2722837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.PMID 19396980Read ↗

Targeting cellular senescence in cancer and aging: roles of p53 and its isoformsSemantic proximity Read ↗

p63 deficiency activates a program of cellular senescence and leads to accelerated aging.Semantic proximity Read ↗

Insights into aging obtained from p53 mutant mouse models.Semantic proximity Read ↗

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model.Semantic proximity Read ↗

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of miceSemantic proximity Read ↗

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related DiseasesSemantic proximity Read ↗

Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Semantic proximity Read ↗

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.Semantic proximity Read ↗

Linked regulation of genome integrity and senescence-associated inflammation by p53Semantic proximity Read ↗

Impaired immune surveillance accelerates accumulation of senescent cells and agingSemantic proximity Read ↗

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.Semantic proximity Read ↗

Regulation of cellular senescence by p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.