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Article

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

Genes & development - 15 Jan 2003

Cao Liu, Li Wenmei, Kim Sangsoo, Brodie Steven G, Deng Chu-Xia

Abstract excerpt

Senescence may function as a two-edged sword that brings unexpected consequences to organisms. Here we provide evidence to support this theory by showing that the absence of the Brca1 full-length isoform causes senescence in mutant embryos and cultured cells as well as aging and tumorigenesis in adult mice. Haploid loss of p53 overcame embryonic senescence but failed to prevent the adult mutant mice from...

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Identifiers

PMID: 12533509
DOI: 10.1101/gad.1050003
PMCID: PMC195980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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