Article
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.
Cell cycle (Georgetown, Tex.) - 15 Aug 2010
Tavana Omid, Benjamin Cara L, Puebla-Osorio Nahum, Sang Mei, Ullrich Stephen E, Ananthaswamy Honnavara N, Zhu Chengming
Abstract excerpt
Genotoxic stress triggers the p53 tumor suppressor network to activate cellular responses that lead to cell cycle arrest, DNA repair, apoptosis or senescence. This network functions mainly through transactivation of different downstream targets, including cell cycle inhibitor p21, which is required for short-term cell cycle arrest or long-term cellular senescence, or proapoptotic genes such as p53 upregulated...
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