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Article

p63 deficiency activates a program of cellular senescence and leads to accelerated aging.

Genes & development - 1 Sept 2005

Keyes William M, Wu Ying, Vogel Hannes, Guo Xuecui, Lowe Scott W, Mills Alea A

Abstract excerpt

The p53 tumor suppressor plays a key role in organismal aging. A cellular mechanism postulated to drive the aging process is cellular senescence, mediated in part by p53. Although senescent cells accumulate in elderly individuals, most studies have relied on correlating in vitro senescence assays with in vivo phenotypes of aging. Here, using two different mouse models in which the p53-related protein p63 is...

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Identifiers

PMID: 16107615
DOI: 10.1101/gad.342305
PMCID: PMC1199570

Genes

PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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