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Article

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.

Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2007

Feng Zhaohui, Hu Wenwei, Teresky Angelika K, Hernando Eva, Cordon-Cardo Carlos, Levine Arnold J

Abstract excerpt

Cancer is a disease of aging. The accumulation of mutations in individual cells over a lifetime is thought to be the reason. In this work, we explored an additional hypothesis: could p53 function decline with age, which would contribute to an enhanced mutation frequency and tumorigenesis in the aging process? The efficiency of the p53 response to gamma-irradiation was found to decline significantly in various...

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Identifiers

PMID: 17921246
DOI: 10.1073/pnas.0708043104
PMCID: PMC2034252

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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