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Article

Regulation of cellular senescence by p53.

European journal of biochemistry - 1 May 2001

Itahana K, Dimri G, Campisi J

Abstract excerpt

Many normal cells respond to potentially oncogenic stimuli by undergoing cellular senescence, a state of irreversibly arrested proliferation and altered differentiated function. Cellular senescence very likely evolved to suppress tumorigenesis. In support of this idea, it is regulated by several tumor suppressor genes. At the heart of this regulation is p53. p53 is essential for the senescence response to short...

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PMID: 11358493
DOI: 10.1046/j.1432-1327.2001.02228.x

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