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Article

Insights into aging obtained from p53 mutant mouse models.

Annals of the New York Academy of Sciences - 1 Jun 2004

Dumble Melissa, Gatza Catherine, Tyner Stuart, Venkatachalam Sundaresan, Donehower Lawrence A

Abstract excerpt

Cancer suppression is an integral component of longevity in organisms with renewable tissues. A number of genes in the mammalian genome function in cancer prevention, and some of these have been directly implicated in longevity assurance. One such longevity assurance gene is the tumor suppressor p53, a transcription factor that is mutated or dysregulated in most human cancers. Early studies have linked p53 to the...

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Identifiers

PMID: 15247009
DOI: 10.1196/annals.1297.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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