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Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms

1 Jul 2020

Abstract excerpt

Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP or through cellular reprogramming represents a novel therapeutic avenue for treating cancer- and age-related diseases such as neurodegeneration, pulmonary fibrosis and renal disease. Cellular senescence is partly regulated by the TP53 gene, a...

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PMID: 32619002
DOI: 10.1093/carcin/bgaa071

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