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Article

Impaired immune surveillance accelerates accumulation of senescent cells and aging

17 Dec 2018

Abstract excerpt

Abstract Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation. The extent of immune-system involvement in regulating age-related accumulation of senescent cells, and its consequences, are...

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PMID: 30575733
DOI: 10.1038/s41467-018-07825-3

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