Article
Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning.
Development (Cambridge, England) - 1 May 2009
Serluca Fabrizio C, Xu Bo, Okabe Noriko, Baker Kari, Lin Shin-Yi, Sullivan-Brown Jessica, Konieczkowski David J, Jaffe Kimberly M, Bradner Joshua M, Fishman Mark C, Burdine Rebecca D
Abstract excerpt
Cilia defects have been implicated in a variety of human diseases and genetic disorders, but how cilia motility contributes to these phenotypes is still unknown. To further our understanding of how cilia function in development, we have cloned and characterized two alleles of seahorse, a zebrafish mutation that results in pronephric cysts. seahorse encodes Lrrc6l, a leucine-rich repeat-containing protein that is...
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