Article

Acute knockdown of extracellular matrix protein Tinagl1 disrupts heart laterality and pronephric cilia in zebrafish embryonic development

2020-06-06

Abstract excerpt

A highly-conserved extracellular matrix protein, Tinagl1, modulates Wnt, integrin, TGF-β, and EGF-R signaling in vitro, but its significance in vivo has remained in doubt. To bypass possible genetic compensation by an ortholog encoded exclusively in mammalian genomes, we examine Tinagl1 function in zebrafish embryos. In this model, tinagl1 mRNA is detected in the developing spinal cord and pronephros. Acute kno...

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Literature Corpus work: 1bc14b1b-4350-5f37-9106-e3f4b4406e27
DOI: 10.1101/2020.06.05.136747

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