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Article

ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition.

Gastroenterology - 1 Aug 2009

Herbst Andreas, Bommer Guido T, Kriegl Lydia, Jung Andreas, Behrens Andrea, Csanadi Endy, Gerhard Markus, Bolz Christian, Riesenberg Rainer, Zimmermann Wolfgang, Dietmaier Wolfgang, Wolf Isabella, Brabletz Thomas, Göke Burkhard, Kolligs Frank T

Abstract excerpt

BACKGROUND & AIMS: The ubiquitously expressed basic helix-loop-helix transcription factor ITF-2B has an important role in differentiation processes, and its transcription is regulated by beta-catenin. The ITF-2 gene is located in the chromosomal region 18q21; allelic loss of this locus occurs in 70% of colorectal cancers. We analyzed the expression, regulation, and function of ITF-2B in colorectal carcinogenesis....

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19394332
DOI: 10.1053/j.gastro.2009.04.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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