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Article

<i>TPX2</i> and <i>AURKA</i> promote 20q amplicon-driven colorectal adenoma to carcinoma progression

29 Dec 2011

Abstract excerpt

BACKGROUND AND OBJECTIVE: Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q amplicon may drive carcinogenesis. The aim of this study was to identify genes located on the 20q...

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PMID: 22207630
DOI: 10.1136/gutjnl-2011-301153

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