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Article

Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.

Cancer research - 15 Aug 2000

Jaffrey R G, Pritchard S C, Clark C, Murray G I, Cassidy J, Kerr K M, Nicolson M C, McLeod H L

Abstract excerpt

Genomic instability is observed in the majority of human tumors. Dysregulation of the mitotic spindle checkpoint is thought to be one of the mechanisms that facilitate aneuploidy in tumor cells. Mutations in the mitotic spindle checkpoint kinase BLUB1 cause a dominant negative disruption of the spindle, leading to chromosome instability in cancer cell lines. However, little is known about chromosome 2q14, the...

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Source

Identifiers

PMID: 10969775

Genes

BUB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.PMID 10969775Read ↗

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