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Article

Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.

Genes, chromosomes & cancer - 1 Jun 2005

Nakano Tetsuhiro, Tani Masachika, Nishioka Michiho, Kohno Takashi, Otsuka Ayaka, Ohwada Susumu, Yokota Jun

Abstract excerpt

Allelic imbalance (AI) on chromosome arm 22q has been detected in 20%-40% of colorectal cancers, suggesting that this chromosome arm has a tumor-suppressor gene involved in colorectal carcinogenesis. Recently, we isolated a candidate tumor-suppressor gene, MYO18B, at 22q12.1, that is deleted, mutated, and hypermethylated in more than 50% of lung cancers. In the present study, we analyzed genetic and epigenetic...

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PMID: 15751041
DOI: 10.1002/gcc.20180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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