Article
SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.
Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2001
Woodford-Richens K L, Rowan A J, Gorman P, Halford S, Bicknell D C, Wasan H S, Roylance R R, Bodmer W F, Tomlinson I P
Abstract excerpt
Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and SMAD2 genes. Recently, the importance of SMAD4, a downstream regulator in the TGF-beta signaling pathway, in colorectal cancer has been highlighted, although the frequency of SMAD4 mutations appears much lower than that of 18q21 loss. We set out to investigate allele loss,...
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