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Article

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.

Journal of gastroenterology - 1 Oct 2016

Belharazem Djeda, Magdeburg Julia, Berton Ann-Kristin, Beissbarth Li, Sauer Christian, Sticht Carsten, Marx Alexander, Hofheinz Ralf, Post Stefan, Kienle Peter, Ströbel Philipp

Abstract excerpt

BACKGROUND: Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. METHODS: Tumor biopsies and paired normal mucosa from 399 patients with extensive clinical annotations were analyzed for LOI and IGF2 expression. LOI status in 140 informative cases...

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Source

Identifiers

PMID: 26984550
DOI: 10.1007/s00535-016-1181-5

Genes

IGF2
AKT1
APC
BRCA2
CDK1
CEACAM6
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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