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Article

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer.

Gastroenterology - 1 Jun 1998

Martínez-López E, Abad A, Font A, Monzó M, Ojanguren I, Pifarré A, Sánchez J J, Martín C, Rosell R

Abstract excerpt

BACKGROUND & AIMS: Loss of heterozygosity (LOH) on chromosome 18q is frequent in colorectal cancer (CRC) and has been associated with poor prognosis in stage II tumors. This study investigated the frequency of LOH in sporadic CRC and its effect on patient prognosis. METHODS: One hundred forty-four patients were screened for LOH at 18q by polymerase chain reaction using three polymorphic microsatellite markers....

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Identifiers

PMID: 9609754
DOI: 10.1016/s0016-5085(98)70423-8

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