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Article

Twist1 induces chromosomal instability (CIN) in colorectal cancer cells

23 Apr 2020

Abstract excerpt

Twist1 is a basic helix-loop-helix transcription factor, essential during early development in mammals. While Twist1 induces epithelial-to-mesenchymal transition (EMT), here we show that Twist1 overexpression enhances nuclear and mitotic aberrations. This is accompanied by an increase in whole chromosomal copy number gains and losses, underscoring the role of Twist1 in inducing chromosomal instability (CIN) in...

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PMID: 32337580
DOI: 10.1093/hmg/ddaa076

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