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Article

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.

Blood - 1 Jun 2007

Zwerts Femke, Lupu Florea, De Vriese Astrid, Pollefeyt Saskia, Moons Lieve, Altura Rachel A, Jiang Yuying, Maxwell Patrick H, Hill Peter, Oh Hideyasu, Rieker Claus, Collen Désiré, Conway Simon J, Conway Edward M

Abstract excerpt

We explored the physiologic role of endothelial cell apoptosis during development by generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in endothelium. This was accomplished by intercrossing survivin(lox/lox) mice with mice expressing cre recombinase under the control of the endothelial cell specific tie1 promoter (tie1-cre mice). Lack of endothelial cell survivin resulted in...

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Identifiers

PMID: 17299096
DOI: 10.1182/blood-2006-06-028068
PMCID: PMC1885533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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