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Article

Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD).

Human mutation - 1 Apr 2006

Baird Paul N, Richardson Andrea J, Robman Luba D, Dimitrov Peter N, Tikellis Gabriella, McCarty Catherine A, Guymer Robyn H

Abstract excerpt

Progression of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, was followed in a cohort of 238 individuals from a single center. Individuals with an epsilon (epsilon)2 genotype (c.526C>T of reference sequence NM_000041.2) of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to...

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Source

Identifiers

PMID: 16453339
DOI: 10.1002/humu.20288

Genes

APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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