Article
New loci and coding variants confer risk for age-related macular degeneration in East Asians.
Nature communications - 28 Jan 2015
Cheng Ching-Yu, Yamashiro Kenji, Chen Li Jia, Ahn Jeeyun, Huang Lulin, Huang Lvzhen, Cheung Chui Ming G, Miyake Masahiro, Cackett Peter D, Yeo Ian Y, Laude Augustinus, Mathur Ranjana, Pang Junxiong, Sim Kar Seng, Koh Adrian H, Chen Peng, Lee Shu Yen, Wong Doric, Chan Choi Mun, Loh Boon Kwang, Sun Yaoyao, Davila Sonia, Nakata Isao, Nakanishi Hideo, Akagi-Kurashige Yumiko, Gotoh Norimoto, Tsujikawa Akitaka, Matsuda Fumihiko, Mori Keisuke, Yoneya Shin, Sakurada Yoichi, Iijima Hiroyuki, Iida Tomohiro, Honda Shigeru, Lai Timothy Yuk Yau, Tam Pancy Oi Sin, Chen Haoyu, Tang Shibo, Ding Xiaoyan, Wen Feng, Lu Fang, Zhang Xiongze, Shi Yi, Zhao Peiquan, Zhao Bowen, Sang Jinghong, Gong Bo, Dorajoo Rajkumar, Yuan Jian-Min, Koh Woon-Puay, van Dam Rob M, Friedlander Yechiel, Lin Ying, Hibberd Martin L, Foo Jia Nee, Wang Ningli, Wong Chang Hua, Tan Gavin S, Park Sang Jun, Bhargava Mayuri, Gopal Lingam, Naing Thet, Liao Jiemin, Ong Peng Guan, Mitchell Paul, Zhou Peng, Xie Xuefeng, Liang Jinlong, Mei Junpu, Jin Xin, Saw Seang-Mei, Ozaki Mineo, Mizoguchi Takanori, Kurimoto Yasuo, Woo Se Joon, Chung Hum, Yu Hyeong-Gon, Shin Joo Young, Park Dong Ho, Kim In Taek, Chang Woohyok, Sagong Min, Lee Sang-Joon, Kim Hyun Woong, Lee Ji Eun, Li Yi, Liu Jianjun, Teo Yik Ying, Heng Chew Kiat, Lim Tock Han, Yang Suk-Kyun, Song Kyuyoung, Vithana Eranga N, Aung Tin, Bei Jin Xin, Zeng Yi Xin, Tai E Shyong, Li Xiao Xin, Yang Zhenglin, Park Kyu-Hyung, Pang Chi Pui, Yoshimura Nagahisa, Wong Tien Yin, Khor Chiea Chuen
Abstract excerpt
Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The Genetics of AMD in Asians (GAMA) Consortium. We find a strong...
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