Article
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.
Human mutation - 1 Dec 2011
McKay Gareth J, Patterson Chris C, Chakravarthy Usha, Dasari Shilpa, Klaver Caroline C, Vingerling Johannes R, Ho Lintje, de Jong Paulus T V M, Fletcher Astrid E, Young Ian S, Seland Johan H, Rahu Mati, Soubrane Gisele, Tomazzoli Laura, Topouzis Fotis, Vioque Jesus, Hingorani Aroon D, Sofat Reecha, Dean Michael, Sawitzke Julie, Seddon Johanna M, Peter Inga, Webster Andrew R, Moore Anthony T, Yates John R W, Cipriani Valentina, Fritsche Lars G, Weber Bernhard H F, Keilhauer Claudia N, Lotery Andrew J, Ennis Sarah, Klein Michael L, Francis Peter J, Stambolian Dwight, Orlin Anton, Gorin Michael B, Weeks Daniel E, Kuo Chia-Ling, Swaroop Anand, Othman Mohammad, Kanda Atsuhiro, Chen Wei, Abecasis Goncalo R, Wright Alan F, Hayward Caroline, Baird Paul N, Guymer Robyn H, Attia John, Thakkinstian Ammarin, Silvestri Giuliana
Abstract excerpt
Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.