Article
Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center.
Investigative ophthalmology & visual science - 1 May 2004
Zareparsi Sepideh, Reddick Adam C, Branham Kari E H, Moore Kathryn B, Jessup Laurie, Thoms Susan, Smith-Wheelock Michael, Yashar Beverly M, Swaroop Anand
Abstract excerpt
PURPOSE: To examine the effect of apolipoprotein E (APOE) alleles on age-related macular degeneration (AMD) risk and on age at diagnosis of AMD in a large patient cohort recruited from a single center. METHODS: The frequency of APOE alleles was analyzed in 632 unrelated AMD patients and 206 unrelated controls, all of whom were of white ancestry. The presence or absence of disease symptoms in all patients and...
Topics
- Aged
- Alleles
- Apolipoprotein E4
- Apolipoproteins E
- Cohort Studies
- DNA
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype