Article
Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2009
Fishman Sarah L, Factor Stephanie H, Balestrieri Cinzia, Fan Xiaofeng, Dibisceglie Adrian M, Desai Suresh M, Benson Gary, Branch Andrea D
Abstract excerpt
PURPOSE: Hepatitis C virus (HCV) infection can promote the development of hepatocellular carcinoma (HCC). Published data implicate the HCV core gene in oncogenesis. We tested the hypothesis that core gene sequences from HCC patients differ from those of patients without cirrhosis/HCC. EXPERIMENTAL DESIGN: Full-length HCV sequences from HCC patients and controls were obtained from the investigators and GenBank and...
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