Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development.

Journal of hepatology - 1 Jan 2010

Nakamoto Shingo, Imazeki Fumio, Fukai Kenichi, Fujiwara Keiichi, Arai Makoto, Kanda Tatsuo, Yonemitsu Yutaka, Yokosuka Osamu

Abstract excerpt

BACKGROUND & AIMS: To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC). METHODS: We followed up 361 patients (median duration, 121 months), and IFN monotherapy was administered to 275 (76%) [sustained virological response (SVR) rate, 26.5%]. Using pretreatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Hepatitis C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferons

Share to Liver Neoplasms

Share to Longitudinal Studies

Share to Proportional Hazards Models

Share to Viral Core Proteins

Share to Viral Load

Source

Identifiers

PMID: 19910070
DOI: 10.1016/j.jhep.2009.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development.PMID 19910070Read ↗

Amino acid substitutions in the hepatitis C Virus core region and lipid metabolism are associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy.Semantic proximity Read ↗

Polymorphisms of the core, NS3, and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma.Semantic proximity Read ↗

HCV core gene polymorphisms correlate with liver fibrosis but not sustained virological response in patients with genotype 1 infection.Semantic proximity Read ↗

Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.Semantic proximity Read ↗

Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C.Semantic proximity Read ↗

Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy.Semantic proximity Read ↗

Hepatitis C virus Genotype 1a core gene nucleotide patterns associated with hepatocellular carcinoma risk.Semantic proximity Read ↗

Effect of Hepatitis C Virus Genotype 1b Core and NS5A Mutations on Response to Peginterferon Plus Ribavirin Combination Therapy.Semantic proximity Read ↗

HCV and HCC: clinical update and a review of HCC-associated viral mutations in the core gene.Semantic proximity Read ↗

Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis.Semantic proximity Read ↗

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.Semantic proximity Read ↗

Mutations in the core and NS5A region of hepatitis C virus genotype 1b and correlation with response to pegylated-interferon-alpha 2b and ribavirin combination therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.