Article
Amino acid substitutions in the hepatitis C Virus core region and lipid metabolism are associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy.
Intervirology - 1 Jan 2013
Seko Yuya, Akuta Norio, Suzuki Fumitaka, Kawamura Yusuke, Sezaki Hitomi, Suzuki Yoshiyuki, Hosaka Tetsuya, Kobayashi Masahiro, Kobayashi Mariko, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu
Abstract excerpt
BACKGROUND: Substitution of amino acid 70 and/or 91 in the core region of hepatitis C virus (HCV) genotype 1b (HCV-1b) is an important predictor of hepatocellular carcinoma (HCC), but its impact on HCC in nonresponders to interferon (IFN) and ribavirin (RIB) combination therapy is not clear. METHODS: A total of 292 patients with HCV-1b-related chronic liver disease who did not achieve a sustained virological...
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