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Article

The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C.

International journal of cancer - 15 Mar 2012

Nischalke Hans-Dieter, Coenen Martin, Berger Cordula, Aldenhoff Katharina, Müller Tobias, Berg Thomas, Krämer Benjamin, Körner Christian, Odenthal Margarete, Schulze Falko, Grünhage Frank, Nattermann Jacob, Sauerbruch Tilman, Spengler Ulrich

Abstract excerpt

Chronic hepatitis C virus (HCV) infection is a major risk factor for hepatocellular carcinoma (HCC). HCV proteins core and NS3 can bind to toll-like receptor 2 (TLR2) and trigger inflammatory responses. Polymorphisms in the TLR2 gene predispose to various forms of malignancy but have not been studied in HCV-associated HCC. Here, we investigated whether single nucleotide polymorphisms (SNPs), rs4696480, rs5743708,...

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Share to Aged, 80 and over
Share to Carcinoma, Hepatocellular
Share to Hepacivirus
Share to Hepatitis C, Chronic
Share to Interleukin-8
Share to Liver Neoplasms
Share to Toll-Like Receptor 2
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Source

Identifiers

PMID: 21500195
DOI: 10.1002/ijc.26143

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C.PMID 21500195Read ↗

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