Article
A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.
Gastroenterology - 1 Jul 2011
Abu Dayyeh Barham K, Yang May, Fuchs Bryan C, Karl Daniel L, Yamada Suguru, Sninsky John J, O'Brien Thomas R, Dienstag Jules L, Tanabe Kenneth K, Chung Raymond T
Abstract excerpt
BACKGROUND & AIMS: A single nucleotide polymorphism 61*G (rs4444903) in the epidermal growth factor (EGF) gene has been associated, in 2 case-control studies, with hepatocellular carcinoma (HCC). We tested associations between demographic, clinical, and genetic data and development of HCC, and developed a simple predictive model in a cohort of patients with chronic hepatitis C and advanced fibrosis. METHODS:...
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