Article
Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma.
Cancer science - 1 Dec 2009
Hu Zhongjie, Muroyama Ryosuke, Kowatari Norie, Chang Jinhai, Omata Masao, Kato Naoya
Abstract excerpt
Chronic hepatitis C virus (HCV) infection often results in hepatocellular carcinoma (HCC). Previous studies have shown that there might be some characteristic mutations in the core region of HCV related to HCC. Thus, we downloaded and analyzed HCV genotype 1b core gene sequences from HCV databases online to identify them. Based on the information of the sequences, 63 from patients with HCC and 188 from non-HCC...
Topics
- Amino Acid Sequence
- Carcinoma, Hepatocellular
- Hepacivirus
- Hepatitis C, Chronic
- Humans
- Liver Neoplasms
- Logistic Models
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- RNA, Viral