Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.

doi:10.3390/v13050743

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Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.

Viruses - 23 Apr 2021

Alkhatib Mohammad, Di Maio Velia Chiara, De Murtas Valentina, Polilli Ennio, Milana Martina, Teti Elisabetta, Fiorentino Gianluca, Calvaruso Vincenza, Barbaliscia Silvia, Bertoli Ada, Scutari Rossana, Carioti Luca, Cento Valeria, Santoro Maria Mercedes, Orro Alessandro, Maida Ivana, Lenci Ilaria, Sarmati Loredana, Craxì Antonio, Pasquazzi Caterina, Parruti Giustino, Babudieri Sergio, Milanesi Luciano, Andreoni Massimo, Angelico Mario, Perno Carlo Federico, Ceccherini-Silberstein Francesca, Svicher Valentina, Salpini Romina, On Behalf Of Hirma Hepatocarcinoma Innovative Research MArkers And Fondazione Vironet C Hcv Virology Italian Resistance

Abstract excerpt

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33922732
DOI: 10.3390/v13050743
PMCID: PMC8146897

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