Article
Polymorphisms of the core, NS3, and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) - 1 Aug 2013
El-Shamy Ahmed, Shindo Michiko, Shoji Ikuo, Deng Lin, Okuno Tadao, Hotta Hak
Abstract excerpt
UNLABELLED: Hepatocellular carcinoma (HCC) is one of the common sequelae of hepatitis C virus (HCV) infection. It remains controversial, however, whether HCV itself plays a direct role in the development of HCC. Although HCV core, NS3, and NS5A proteins were reported to display tumorigenic activities in cell culture and experimental animal systems, their clinical impact on HCC development in humans is still...
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