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Article

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

Journal of cell science - 15 May 2009

Haigh Cathryn L, Drew Simon C, Boland Martin P, Masters Colin L, Barnham Kevin J, Lawson Victoria A, Collins Steven J

Abstract excerpt

Beta-cleavage of the neurodegenerative disease-associated prion protein (PrP) protects cells from death induced by oxidative insults. The beta-cleavage event produces two fragments, designated N2 and C2. We investigated the role of the N2 fragment (residues 23-89) in cellular stress response, determining mechanisms involved and regions important for this reaction. The N2 fragment differentially modulated the...

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Identifiers

PMID: 19383722
DOI: 10.1242/jcs.043604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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