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Article

Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.

PloS one - 8 Feb 2010

Oliveira-Martins José B, Yusa Sei-ichi, Calella Anna Maria, Bridel Claire, Baumann Frank, Dametto Paolo, Aguzzi Adriano

Abstract excerpt

The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the alpha site (109K [see text]H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that alpha-cleavage is important for PrP(C) physiology. To gain insights...

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Source

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Identifiers

PMID: 20161712
DOI: 10.1371/journal.pone.0009107
PMCID: PMC2817006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20161712-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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