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Article

The N-terminal, polybasic region is critical for prion protein neuroprotective activity.

PloS one - 1 Jan 2011

Turnbaugh Jessie A, Westergard Laura, Unterberger Ursula, Biasini Emiliano, Harris David A

Abstract excerpt

Several lines of evidence suggest that the normal form of the prion protein, PrP(C), exerts a neuroprotective activity against cellular stress or toxicity. One of the clearest examples of such activity is the ability of wild-type PrP(C) to suppress the spontaneous neurodegenerative phenotype of transgenic mice expressing a deleted form of PrP (Δ32-134, called F35). To define domains of PrP involved in its...

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Identifiers

PMID: 21980526
DOI: 10.1371/journal.pone.0025675
PMCID: PMC3183058

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