Article
Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress.
The Journal of biological chemistry - 28 Oct 2005
Watt Nicole T, Taylor David R, Gillott Andrew, Thomas Daniel A, Perera W Sumudhu S, Hooper Nigel M
Abstract excerpt
The cellular prion protein (PrP(C)) is critical for the development of prion diseases. However, the physiological role of PrP(C) is less clear, although a role in the cellular resistance to oxidative stress has been proposed. PrP(C) is cleaved at the end of the copper-binding octapeptide repeats through the action of reactive oxygen species (ROS), a process termed beta-cleavage. Here we show that ROS-mediated...
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