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Article

Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site.

Biochemistry - 7 Aug 2012

D'Angelo Paola, Della Longa Stefano, Arcovito Alessandro, Mancini Giordano, Zitolo Andrea, Chillemi Giovanni, Giachin Gabriele, Legname Giuseppe, Benetti Federico

Abstract excerpt

Prion diseases are a class of fatal neurodegenerative disorders characterized by brain spongiosis, synaptic degeneration, microglia and astrocytes activation, neuronal loss and altered redox control. These maladies can be sporadic, iatrogenic and genetic. The etiological agent is the prion, a misfolded form of the cellular prion protein, PrP(C). PrP(C) interacts with metal ions, in particular copper and zinc,...

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Identifiers

PMID: 22788868
DOI: 10.1021/bi300233n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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