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Article

Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation.

Journal of molecular biology - 24 Jul 2020

Schilling Kevin M, Tao Lizhi, Wu Bei, Kiblen Joseph T M, Ubilla-Rodriguez Natalia C, Pushie M Jake, Britt R David, Roseman Graham P, Harris David A, Millhauser Glenn L

Abstract excerpt

The cellular prion protein (PrPC) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain. Recently, copper has been observed to drive tertiary contact in PrPC, inducing a neuroprotective cis interaction that structurally links the protein's two domains. The location of this interaction on the C terminus overlaps with the sites of human pathogenic mutations and toxic antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32473880
DOI: 10.1016/j.jmb.2020.05.020
PMCID: PMC7387163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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