Article
Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression.
The Journal of clinical investigation - 1 May 2009
Papeta Natalia, Chan Ka-Tak, Prakash Sindhuri, Martino Jeremiah, Kiryluk Krzysztof, Ballard David, Bruggeman Leslie A, Frankel Rachelle, Zheng Zongyu, Klotman Paul E, Zhao Hongyu, D'Agati Vivette D, Lifton Richard P, Gharavi Ali G
Abstract excerpt
Multiple studies have linked podocyte gene variants to diverse sporadic nephropathies, including HIV-1-associated nephropathy (HIVAN). We previously used linkage analysis to identify a major HIVAN susceptibility locus in mouse, HIVAN1. We performed expression quantitative trait locus (eQTL) analysis of podocyte genes in HIV-1 transgenic mice to gain further insight into genetic susceptibility to HIVAN. In 2...
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