Article
GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus.
Journal of the American Society of Nephrology : JASN - 1 Jan 2022
Steers Nicholas J, Gupta Yask, D'Agati Vivette D, Lim Tze Y, DeMaria Natalia, Mo Anna, Liang Judy, Stevens Kelsey O, Ahram Dina F, Lam Wan Yee, Gagea Mihai, Nagarajan Lalitha, Sanna-Cherchi Simone, Gharavi Ali G
Abstract excerpt
BACKGROUND: To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN). METHODS: We first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ background and 20 inbred laboratory...
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