Article
Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy.
Kidney international - 1 Sept 2005
Zhong Jianyong, Zuo Yiqin, Ma Ji, Fogo Agnes B, Jolicoeur Paul, Ichikawa Iekuni, Matsusaka Taiji
Abstract excerpt
BACKGROUND: Human immunodeficiency virus (HIV)-1-associated nephropathy (HIVAN) is characterized by collapsing focal and segmental glomerulosclerosis (FSGS) and microcystic tubular dilatation. HIV-1 infection is also associated with other forms of nephropathy, including mesangial hyperplasia. Since HIV-1 gene products are detected in podocytes and other renal cells, it remains uncertain whether...
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