Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-6 Modulates CD5 Expression in B Cells from Patients with Lupus by Regulating DNA Methylation

21 Apr 2009

Abstract excerpt

B lymphocytes from patients with systemic lupus erythematosus (SLE) are characterized by reduced expression levels of membrane CD5. Recent studies from our laboratory have revealed that the level of membrane CD5 is determined by the relative level of two alternative CD5 isoforms; CD5-E1A, which is expressed on the membrane, and CD5-E1B, which is retained in the cytoplasm. Using bisulfite sequencing and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Systemic Lupus Erythematosus Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19380809
DOI: 10.4049/jimmunol.0802412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-6 Modulates CD5 Expression in B Cells from Patients with Lupus by Regulating DNA MethylationPMID 19380809Read ↗

DNA methylation modulates HRES1/p28 expression in B cells from patients with LupusSemantic proximity Read ↗

CD5 Expression in B Cells from Patients with Systemic Lupus ErythematosusSemantic proximity Read ↗

Deoxyribonucleic Acid Methylation in Systemic Lupus Erythematosus: Implications for Future Clinical PracticeSemantic proximity Read ↗

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.Semantic proximity Read ↗

RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.Semantic proximity Read ↗

Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip.Semantic proximity Read ↗

Associations between the Expression of Epigenetically Regulated Genes and the Expression of DNMTs and MBDs in Systemic Lupus ErythematosusSemantic proximity Read ↗

Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLESemantic proximity Read ↗

The genetics and biology of Irf5-mediated signaling in lupusSemantic proximity Read ↗

Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects.Semantic proximity Read ↗

Population‐Specific Patterns of Epigenetic Defects in the B Cell Lineage in Patients With Systemic Lupus ErythematosusSemantic proximity Read ↗

An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.