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Article

CD5 Expression in B Cells from Patients with Systemic Lupus Erythematosus

1 Jan 2011

Abstract excerpt

The recently recognized importance of B cells in systemic lupus erythematosus (SLE) raises the question as to whether those expressing CD5 predominate over the remaining B lymphocytes in the pathophysiology of this disease. Owing to their B B-cell receptor (BCR) polyspecificity, autoantibody production has been originally ascribed to CD5-positive B1 lymphocytes. Instead, it has since been established that...

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PMID: 21395509
DOI: 10.1615/critrevimmunol.v31.i1.30

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