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Article

Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment.

Journal of cellular and molecular medicine - 1 Mar 2009

Hrstka Roman, Coates Philip J, Vojtesek Borivoj

Abstract excerpt

The p53 tumour suppressor protein lies at the crossroads of multiple cellular response pathways that control the fate of the cell in response to endogenous or exogenous stresses and inactivation of the p53 tumour suppressor signalling pathway is seen in most human cancers. Such aberrant p53 activity may be caused by mutations in the TP53 gene sequence producing truncated or inactive mutant proteins, or by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19379143
DOI: 10.1111/j.1582-4934.2008.00634.x
PMCID: PMC3822507

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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