Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer.

Mutagenesis - 1 Mar 2012

Naccarati A, Polakova V, Pardini B, Vodickova L, Hemminki K, Kumar R, Vodicka P

Abstract excerpt

A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in tumours. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Genetic Predisposition to Disease

Share to Mutation

Share to Polymorphism, Genetic

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 22294769
DOI: 10.1093/mutage/ger067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer.PMID 22294769Read ↗

TP53 mutations in human cancers: origins, consequences, and clinical use.Semantic proximity Read ↗

Different mutation profiles associated to P53 accumulation in colorectal cancer.Semantic proximity Read ↗

TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis.Semantic proximity Read ↗

Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment.Semantic proximity Read ↗

R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history.Semantic proximity Read ↗

Common genetic variants in the TP53 pathway and their impact on cancerSemantic proximity Read ↗

[Genetic variations of the tumor suppressor TP53: outstanding and strategies of analysis].Semantic proximity Read ↗

p53 polymorphisms: cancer implications.Semantic proximity Read ↗

Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.Semantic proximity Read ↗

Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis.Semantic proximity Read ↗

Studying the Impact of Tp53 Mutations on Colorectal Cancer Pathogenesis and Therapeutic Response in a Tunisian PopulationSemantic proximity Read ↗

Somatic mutations in human cancer: applications in molecular epidemiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.