Article

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

2019-11-09

Abstract excerpt

Insights into oncogenesis derived from cancer susceptibility loci could facilitate better cancer management and treatment through precision oncology. However, therapeutic applications have thus far been limited by our current lack of understanding regarding both their interactions with somatic cancer driver mutations and their influence on tumorigenesis. Here, by integrating germline datasets relating to cancer su...

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Literature Corpus work: da14d332-2d7e-5fc0-af58-b11f097f956a
DOI: 10.1101/835918

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