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Article

Clinical outcomes and correlates of TP53 mutations and cancer.

Cold Spring Harbor perspectives in biology - 1 Mar 2010

Robles Ana I, Harris Curtis C

Abstract excerpt

The initial observation that p53 accumulation might serve as a surrogate biomarker for TP53 mutation has been the cornerstone for vast translational efforts aimed at validating its clinical use for the diagnosis, prognosis, and treatment of cancer. Early on, it was realized that accurate evaluation of p53 status and function could not be achieved through protein-expression analysis only. As our understanding of...

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Identifiers

PMID: 20300207
DOI: 10.1101/cshperspect.a001016
PMCID: PMC2829964

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